> That being said high fees don't negatively affect the main retail use cases Bitcoin has demonstrated the best suitably for: cryptolocker payments and contraband.

They do. Hugh fees per tx bite means higher cost for multisig transactions. All on-chain market already use some sort of multisig setup, including legal ones such as OpenBazaar.

Furthermore, this high cost also makes both metacoin protocols, timestamping services, as well as oracle services (smart contracts) very costly.