What you can do is get wheel packages for all your dependencies and install them from a local "wheelhouse":

    pip install -r requirements.txt --no-index --find-links=/path/to/wheelhouse

If for each requirement in `requirements.txt` you have the corresponding wheel file in `/path/to/wheelhouse`, this will not touch the network and complete. I have been using this approach the past 2 years with great success.

You can learn a bit more about wheel in this very good article: http://lucumr.pocoo.org/2014/1/27/python-on-wheels/