I've been doing this for some time but I replaced metformin requires RX with Berberine that is safer based on my research. less risk of lactic acidosis of the liver. I found that it's hard to find a sweet spot with DHEA. Too much leads to easy bruising.

I actually prefer pregnenolone to DHEA, I've found it to be more forgiving. I agree wrt Berberine, the lactic acidosis issue turned me off metformin as well. I believe it's the reason Peter Attia stopped using it also.

Peter Thiel just needs to add in the metformin and DHEA and his thymus rejuvenation will be complete.