Learned phonotactics matters, though, and many languages distinguish between what's allowed on word or morpheme boundaries vs what's allowed within a single syllable - so even if phonemically it's the same cluster, it can still be difficult to learn to pronounce it correctly in the second case.
There are quite a few languages where both vowel and consonant systems are simple - just look at Polynesian languages such as Māori. The latter's vowel system is 5-vowel, and "long vowels" are phonemically vowel sequences that span moras. But, yes, it does mean that you end up with long words such as "whakararurarutia". That said, it's a rather extreme case, and one can still construct fairly simple but rich consonant systems in practice, because it's basically combinatorics - adding just one more bit of information doubles the domain space! So e.g. if you start with a strict CV consonant system and allow C(l/r)V, that's almost 4x as many contrasting syllables. Make it C(l/r/w/y)V(C) like in Globasa, and even with considerable restrictions on clustering stops etc this is enough for most words to be 3 syllables or less, and for most function words to be 1 syllable.
There are quite a few languages where both vowel and consonant systems are simple - just look at Polynesian languages such as Māori. The latter's vowel system is 5-vowel, and "long vowels" are phonemically vowel sequences that span moras. But, yes, it does mean that you end up with long words such as "whakararurarutia". That said, it's a rather extreme case, and one can still construct fairly simple but rich consonant systems in practice, because it's basically combinatorics - adding just one more bit of information doubles the domain space! So e.g. if you start with a strict CV consonant system and allow C(l/r)V, that's almost 4x as many contrasting syllables. Make it C(l/r/w/y)V(C) like in Globasa, and even with considerable restrictions on clustering stops etc this is enough for most words to be 3 syllables or less, and for most function words to be 1 syllable.